Epigenetics in congenital diseases and pervasive developmental disorders
نویسندگان
چکیده
منابع مشابه
Epigenetics in congenital diseases and pervasive developmental disorders.
Epigenetics is an intrinsic mechanism that alters gene function - not by altering DNA sequences, but by chemically modifying the DNA and chromosomal histone proteins. Epigenetics is involved in genomic imprinting and X-chromosome inactivation in humans, and the failure of this mechanism causes a subset of congenital syndromes and cancers. Until recently, it has been believed that epigenetic mod...
متن کاملEpigenetics and Neural Developmental Disorders
Neural developmental disorders, such as autism, Rett Syndrome, Fragile X syndrome, and Angelman syndrome manifest during early postnatal neural development. Although the genes responsible for some of these disorders have been identified, how the mutations of these genes affect neural development is currently unclear. Emerging evidence suggest that these disorders share common underlying defects...
متن کاملAutism and pervasive developmental disorders.
The quantity and quality of research into autism and related conditions have increased dramatically in recent years. Consequently we selectively review key accomplishments and highlight directions for future research. More consistent approaches to diagnosis and more rigorous assessment methods have significantly advanced research, although the boundaries of the 'broader phenotype' remain to be ...
متن کامل[Autism and pervasive developmental disorders].
OBJECTIVE To review the current knowledge on neurobiological aspects of autism and pervasive developmental disorders, as well as to provide pediatricians with up to date information on diagnosis and treatment of autism. SOURCES OF DATA Review of MEDLINE and Internet. SUMMARY OF THE FINDINGS Autism is the 3rd developmental disorder, with an incidence of 40 to 130/100,000 individuals. Diagnos...
متن کاملPervasive Developmental Disorders: Indian Scene
Pervasive developmental disorders (PDDs) are characterized by slow, limited and atypical developmental processes with onset in the early years of life. The condition leads on to disabilities in virtually all the psychological and behavioral sectors with prominent disturbances in social, communicative and cognitive spheres. PDDs include the prototypic Childhood autism, Rett’s syndrome, Childhood...
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ژورنال
عنوان ژورنال: Environmental Health and Preventive Medicine
سال: 2007
ISSN: 1342-078X,1347-4715
DOI: 10.1007/s12199-007-0008-7